Lagot Ka Sa Kuya Ko revolves around the life of two siblings who grew up in different worlds. Alex (Ronnie Ricketts) is a taxi driver who moonlights as an underground street fighter. His sister Sarah (Nadine Samonte) is a US-bred teenager who just got back in the country with their mother (Marita Zobel). Through Boogie (Dinky Doo), an aspiring rapper whom Alex rescued from a brawl with fraternity guys, he met Sarah and her mother without knowing they were the family he has searched long and hard for.
| Actor | Role |
|---|---|
 Ronnie RickettsAlex | Alex |
 Nadine SamonteSarah | Sarah |
| MMariz RickettsMichelle | Michelle |
| DDinky Doo Jr.Boogie | Boogie |
 Marita ZobelAlex's and Sarah's mother | Alex's and Sarah's mother |
 Carlos MoralesZandro | Zandro |
| JJohn ApacibleNot listed | Not listed |
| RRey BejarNot listed | Not listed |
| JJamie Liz CastilloNot listed | Not listed |
| JJordan CastilloNot listed | Not listed |
| PPatrick Dela RosaNot listed | Not listed |
 Dick IsraelNot listed | Not listed |
| AAngelica JonesNot listed | Not listed |
| JJohn MedinaNot listed | Not listed |
 Gerard PizzarasNot listed | Not listed |
 ShalalaNot listed | Not listed |
| MMarella RickettsNot listed | Not listed |
| IIsko SalvadorNot listed | Not listed |
 Onyok VelascoNot listed | Not listed |