 Jack BlackPo (voice) | Po (voice) |
 Bryan CranstonLi (voice) | Li (voice) |
 Dustin HoffmanShifu (voice) | Shifu (voice) |
 Angelina JolieTigress (voice) | Tigress (voice) |
 J.K. SimmonsKai (voice) | Kai (voice) |
 Jackie ChanMonkey (voice) | Monkey (voice) |
 Seth RogenMantis (voice) | Mantis (voice) |
 Lucy LiuViper (voice) | Viper (voice) |
 David CrossCrane (voice) | Crane (voice) |
 Kate HudsonMei Mei (voice) | Mei Mei (voice) |
 James HongMr. Ping (voice) | Mr. Ping (voice) |
 Randall Duk KimOogway (voice) | Oogway (voice) |
 Steele GagnonBao (voice) | Bao (voice) |
| LLiam KnightLei Lei (voice) | Lei Lei (voice) |
 Wayne KnightBig Fun / Hom-Lee (voice) | Big Fun / Hom-Lee (voice) |
 Barbara DiricksonGrandma Panda (voice) | Grandma Panda (voice) |
 Al RokerSum (voice) | Sum (voice) |
 Willie GeistDim (voice) | Dim (voice) |
 Fred TatascioreMaster Bear (voice) | Master Bear (voice) |
| PPax Jolie-PittYoo (voice) | Yoo (voice) |
 Kelly Cooney CilellaFemale Palace Goose (voice) | Female Palace Goose (voice) |
 Stephen KearinMaster Chicken (voice) | Master Chicken (voice) |
 Mick WingertFarmer Goose / Farmer Rabbit (voice) | Farmer Goose / Farmer Rabbit (voice) |
 Ming TsaiMing (voice) | Ming (voice) |
 April HongMrs. Chow (voice) | Mrs. Chow (voice) |
| KKnox Jolie-PittKu Ku (voice) | Ku Ku (voice) |
| ZZahara JolieMeng Meng (voice) | Meng Meng (voice) |
| SShiloh JolieShuai Shuai (voice) | Shuai Shuai (voice) |
 Jean-Claude Van DammeMaster Croc (voice) | Master Croc (voice) |
 Radzi ChinyanganyaMi (voice) | Mi (voice) |
