Karen, Helen, Joyce, Sandy and Anna are next-door neighbors. They also happen to be the closest of friends. And though they are five different girls, they have one similar problem; their relationship with boys. They end up meeting the wrong guys who do not only break their hearts but also get them into messy situations.
| Actor | Role |
|---|---|
 Jessa ZaragozaSandy | Sandy |
 Rufa Mae QuintoKaren Hipolito | Karen Hipolito |
| CCara MarsanAnna | Anna |
 Erika FifeGrace | Grace |
| RRizza PadillaHelen | Helen |
 Jay ManaloRamon Padilla | Ramon Padilla |
 Lander Vera PerezWillie De Mesa | Willie De Mesa |
| BBrando LegaspiMike Remando | Mike Remando |
 Lee Robin SalazarRick | Rick |
| MMichael GomezJeff Martinez | Jeff Martinez |
 Cita AstalsTita Tot | Tita Tot |
| DDanny 'Brownie' PunzalanBudoy | Budoy |
 Dexter DoriaChuchi | Chuchi |
 Cloyd RobinsonDirek | Direk |
| GGino IlustreTita Tot's Husband | Tita Tot's Husband |
 Archie AdamosMr. Liorente | Mr. Liorente |
| RRey CaneteTwinkie | Twinkie |
| PPanyangRick's 'Mommie' | Rick's 'Mommie' |
| MMadam AuringMommie's Friend | Mommie's Friend |
| KKieth SerranoJojo | Jojo |
| LLoretta LaharaMike's Girlfriend | Mike's Girlfriend |