 Pat O'BrienKnute Rockne | Knute Rockne |
 Gale PageBonnie Skiles Rockne | Bonnie Skiles Rockne |
 Ronald ReaganGeorge Gipp | George Gipp |
 Donald CrispFather John Callahan, C.S.C | Father John Callahan, C.S.C |
 Albert BassermannFather Julius Nieuwland | Father Julius Nieuwland |
 John LitelCommittee Chairman | Committee Chairman |
 Henry O'NeillDoctor | Doctor |
 Owen Davis Jr.Gus Dorais | Gus Dorais |
 John QualenLars Knutson Rockne | Lars Knutson Rockne |
 Dorothy TreeMartha Rockne | Martha Rockne |
 Johnny SheffieldKnute - Age 7 | Knute - Age 7 |
 Nick LukatsHarry Stuhldreher - One of The Four Horsemen | Harry Stuhldreher - One of The Four Horsemen |
 Kane RichmondElmer Laydon - One of The Four Horsemn | Elmer Laydon - One of The Four Horsemn |
 William MarshallDon Miller - One of The Four Horsemen | Don Miller - One of The Four Horsemen |
| WWilliam ByrneJames Crowley - One of The Four Horsemen | James Crowley - One of The Four Horsemen |
 Howard JonesUSC Coach Howard Jones | USC Coach Howard Jones |
| GGlenn 'Pop' WarnerCoach 'Pop' Warner | Coach 'Pop' Warner |
| AAmos Alonzo StaggCoach Alonzo Stagg | Coach Alonzo Stagg |
| WWilliam 'Bill' SpauldingBill Spaulding | Bill Spaulding |
 Erville AldersonKansas Farmer Witnessing Airplane Crash (uncredited) | Kansas Farmer Witnessing Airplane Crash (uncredited) |
 Rudolph AndersElder in Norway (uncredited) | Elder in Norway (uncredited) |
| PPeter AshleyFootball Player (uncredited) | Football Player (uncredited) |
| EEvelyn AtchinsonBathing Beauty (uncredited) | Bathing Beauty (uncredited) |
| TTommy BakerNewsboy (uncredited) | Newsboy (uncredited) |
| JJack BantaPunter (uncredited) | Punter (uncredited) |
| TTommy BennettO'Reilly (uncredited) | O'Reilly (uncredited) |
| GGeorgie BillingsBoy Quarterback (uncredited) | Boy Quarterback (uncredited) |
 Wade BotelerTrainer (uncredited) | Trainer (uncredited) |
 Egon BrecherElder in Norway (uncredited) | Elder in Norway (uncredited) |
 David BruceReporter When Knute is Ill (uncredited) | Reporter When Knute is Ill (uncredited) |
