Investigating the mysterious deaths of a number of farm animals, vet Rack Hansen discovers that his town lies in the path of hordes of migrating tarantulas. Before he can take action, the streets are overrun by killer spiders, trapping a small group of townsfolk in a remote hotel.
| Actor | Role |
|---|---|
 William ShatnerDr. Robert 'Rack' Hansen | Dr. Robert 'Rack' Hansen |
 Tiffany BollingDiane Ashley | Diane Ashley |
 Woody StrodeWalter Colby | Walter Colby |
 Lieux DresslerEmma Washburn | Emma Washburn |
 David McLeanSheriff Gene Smith | Sheriff Gene Smith |
 Natasha RyanLinda Hansen | Linda Hansen |
 Altovise DavisBirch Colby | Birch Colby |
| JJoe RossVern Johnson | Vern Johnson |
 Marcy LaffertyTerry Hansen | Terry Hansen |
 Hoke HowellEarl Forbes | Earl Forbes |
 Adele Malis-MoreyBetty Johnson | Betty Johnson |
| RRoy EngelMayor Connors | Mayor Connors |
 Bill CoontzClyde | Clyde |
| WWhitey HughesThe Baron | The Baron |
| JJay LawrenceDeputy | Deputy |
| BBettie BollingMildred | Mildred |
 Anita MerrittWaitress | Waitress |
| NNadia CaillouScreaming Woman | Screaming Woman |
| VValla Rae McDadeScreaming Woman | Screaming Woman |