 Anna May WongDr. Mary Ling | Dr. Mary Ling |
 Akim TamiroffFrank Baturin | Frank Baturin |
 J. Carrol NaishThe Professor | The Professor |
 Sidney TolerDr. Chang Ling | Dr. Chang Ling |
 Philip AhnRobert 'Bob' Li | Robert 'Bob' Li |
 Anthony QuinnMike Gordon | Mike Gordon |
 Bernadene HayesDolly Warren | Dolly Warren |
 Roscoe KarnsRip Harrigan | Rip Harrigan |
| RRay MayerPotatoes | Potatoes |
 Richard DenningJeff, Protective Association Henchman | Jeff, Protective Association Henchman |
 Archie TwitchellInterne | Interne |
 Eddie MarrBert, Fight Trainer | Bert, Fight Trainer |
| GGeorge AndersonDetective | Detective |
| CCharles B. Wood1st Gangster | 1st Gangster |
 George Magrill2nd Gangster | 2nd Gangster |
 Charles TrowbridgeDr. Jones | Dr. Jones |
| LLily KingChinese Woman | Chinese Woman |
 Chester GanMr. Foo | Mr. Foo |
 Pat WestAnnouncer at Fight | Announcer at Fight |
 Guy UsherInvestigator | Investigator |
 Sam AshBarber (uncredited) | Barber (uncredited) |
 Marie BurtonNightclub Girl (uncredited) | Nightclub Girl (uncredited) |
 Dolores CaseyNightclub Girl (uncredited) | Nightclub Girl (uncredited) |
 Ethel ClaytonNightclub Patron (uncredited) | Nightclub Patron (uncredited) |
 Wong ChungChinese Man (uncredited) | Chinese Man (uncredited) |
| SSheila DarcyNightclub Girl (uncredited) | Nightclub Girl (uncredited) |
 Dorothy DaytonNightclub Girl (uncredited) | Nightclub Girl (uncredited) |
| PPaula DeCardoDancer (uncredited) | Dancer (uncredited) |
| RRaoul FreemanDetective (uncredited) | Detective (uncredited) |
| NNorah GaleNightclub Girl (uncredited) | Nightclub Girl (uncredited) |
