After falling from the Twin Towers, Kong lies in a coma for ten years. When his heart begins to fail, scientists engineer an artificial heart, and a giant female ape is captured to serve as a source for a blood transfusion. When Kong awakens following his heart transplant, he senses the nearby presence of the female ape and the two escape to wreak havoc together.
| Actor | Role |
|---|---|
 Linda HamiltonAmy Franklin | Amy Franklin |
 Brian KerwinHank Mitchell | Hank Mitchell |
| PPeter ElliottKing Kong | King Kong |
 George AntoniLady Kong | Lady Kong |
 John AshtonLt. Col. R.T. Nevitt | Lt. Col. R.T. Nevitt |
 Peter Michael GoetzDr. Andrew Ingersoll | Dr. Andrew Ingersoll |
| FFrank MaradenDr. Benson Hughes | Dr. Benson Hughes |
| RRobin CahallMazlansky | Mazlansky |
| JJimmie Ray WeeksMajor Peete | Major Peete |
 Michael ForestVance | Vance |
| MMarc ClementCrew Chief | Crew Chief |
 Jim GrimshawSergeant | Sergeant |
 Bernard AddisonCaptain #1 | Captain #1 |
 Michael McClendonCaptain #2 | Captain #2 |
 Leon RippyHunter | Hunter |
| DDuke ErnsbergerCell Guard #1 | Cell Guard #1 |
 Mike StarrCell Guard #2 | Cell Guard #2 |
 Jessica LangeDwan (archive footage) | Dwan (archive footage) |
 Jeff BridgesJack Prescott (archive footage) | Jack Prescott (archive footage) |