 Christy Carlson RomanoKim Possible (voice) | Kim Possible (voice) |
 Will FriedleRon Stoppable (voice) | Ron Stoppable (voice) |
 Nancy CartwrightRufus (voice) | Rufus (voice) |
 Tahj MowryWade (voice) | Wade (voice) |
 Mayim BialikJustine Flanner (voice) | Justine Flanner (voice) |
 Gary ColeDr. Possible (voice) | Dr. Possible (voice) |
 John DiMaggioDr. Drakken (voice) | Dr. Drakken (voice) |
 Shaun FlemingJim Possible / Tim Possible (voice) | Jim Possible / Tim Possible (voice) |
 Rob PaulsenHank Perkins (voice) | Hank Perkins (voice) |
 Brian GeorgeDuff Killigan (voice) | Duff Killigan (voice) |
 Tom KaneMonkey Fist (voice) | Monkey Fist (voice) |
 Kerri KenneyAdditional Voices (voice) | Additional Voices (voice) |
 Melissa McCarthyAmy Hall (voice) | Amy Hall (voice) |
 Jean SmartDr. Ann Possible (voice) | Dr. Ann Possible (voice) |
 Kirsten StormsBonnie Rockwaller (voice) | Bonnie Rockwaller (voice) |
 Nicole SullivanShego (voice) | Shego (voice) |
 Raven-SymonéMonique (voice) | Monique (voice) |
 Patrick WarburtonSteve Barkin (voice) | Steve Barkin (voice) |
 Gedde WatanabeProfessor Bob Chen (voice) | Professor Bob Chen (voice) |
 Jo Anne WorleyAdditional Voices (voice) | Additional Voices (voice) |
 Frank WelkerProfessor Otto Allenford (voice) | Professor Otto Allenford (voice) |
 Diedrich BaderLars (voice; uncredited) | Lars (voice; uncredited) |
 Eddie DeezenNed (voice; uncredited) | Ned (voice; uncredited) |
 Clyde KusatsuNakasumi (voice; uncredited) | Nakasumi (voice; uncredited) |
 Maurice LaMarche'Big Daddy' Brotherson (voice; uncredited) | 'Big Daddy' Brotherson (voice; uncredited) |
 Phil LaMarrNinja / Japanese Businessman #2 (voice; uncredited) | Ninja / Japanese Businessman #2 (voice; uncredited) |
 Kevin Michael RichardsonSumo Ninja / Dr. Gooberman / Businessman (voice; uncredited) | Sumo Ninja / Dr. Gooberman / Businessman (voice; uncredited) |
 Stephen RootCowboy Gambler (voice; uncredited) | Cowboy Gambler (voice; uncredited) |
 Rider StrongBrick Flagg (voice; uncredited) | Brick Flagg (voice; uncredited) |
 Tara StrongComputer (voice; uncredited) | Computer (voice; uncredited) |
