Killing Poe is a dark comedy about five students in a class on Edgar Allan Poe who teach their professor a lesson in true Poe style.
| Actor | Role |
|---|---|
 Matt BushJoseph Jefferson | Joseph Jefferson |
 Osric ChauBud Polinski | Bud Polinski |
 Julianna GuillBrittany Wilcox | Brittany Wilcox |
 Cyrina FialloWynona Thompson | Wynona Thompson |
 Sunkrish BalaAshbir Brathwaite | Ashbir Brathwaite |
 Rick PlastinaDr. Reginald Reinhold Lynch | Dr. Reginald Reinhold Lynch |
| FFrank RiceDonor | Donor |
 Lana WoodDean Wood | Dean Wood |
| XXavier LamontBrown | Brown |
| NNancy SellersDr. Judith Rosenburg | Dr. Judith Rosenburg |
| DDale WamboltDr. Destruction | Dr. Destruction |
 Tony AlcantarWynona's Dad | Wynona's Dad |
| BBernard RiceJoe's Father | Joe's Father |
| CChris FirestoneSocial Justice Prof. 2 | Social Justice Prof. 2 |