In the summer of 1859, a widowed physician reluctantly agrees to take a recently freed slave and her mysterious Caucasian daughter on a five-day journey through the bloody West to find a distant town's Faith Healer. The woman believes her daughter is possessed. The doctor believes she simply carries The Sickness. Either way the fact remains that every living thing the girl touches mysteriously dies.
| Actor | Role |
|---|---|
 Guy PearceBender | Bender |
 DeWanda WiseSarah | Sarah |
 Bill PullmanRoss | Ross |
 Raoul Max TrujilloShakespeare | Shakespeare |
 Ryan de QuintalHershel | Hershel |
 Emily Katherine FordThe Girl | The Girl |
 Jack AlcottEdward | Edward |
 Charlie TalbertCotton | Cotton |
 Joanna CassidyMaggie | Maggie |
 Josh McDermittNot listed | Not listed |
 Keith JardineGibson | Gibson |
 Andrew J. WestSheriff Legsplint | Sheriff Legsplint |
 Jamie NeumannWhitey | Whitey |
 Gail CronauerMiss Atwater | Miss Atwater |
 Teagan IrelandAnnie | Annie |
| JJimmy E. JonesSatchel | Satchel |
 Courtney TaylorNarrator(as Courtney Taylor) | Narrator(as Courtney Taylor) |
| CChris OatwayBell Man | Bell Man |
| JJoe CoughlanChicken Man | Chicken Man |
| BBill PetersDrunk | Drunk |
| MMatt ArtisanDeputy 2 | Deputy 2 |
| IIke ShehadehDeputy 1 | Deputy 1 |
| JJacob WoodworthPatron 2 | Patron 2 |
 Nathan WoodworthPatron 1 | Patron 1 |
| HHannah MosquedaRocking Woman | Rocking Woman |
 David S. LeeRoss's Confidant(as David Lee) | Ross's Confidant(as David Lee) |
 Thomas WingateWillard | Willard |
| JJames CadyProprietor(as James Louis Cady) | Proprietor(as James Louis Cady) |
| TTeagan IrelandAnnie | Annie |