Killer Drag Queens on Dope is the wild story of Ginger and Coco, two dolls with a little secret... They're contract killers who work for a one-eyed lunatic named Uncle A. Half the cutthroats in town are trying to kill them, the other half are trying to sleep with them and Uncle A is just getting started. Ginger is hell on heels. Coco never met a drug she didn't like. Together, they're Killer Drag Queens on Dope!
| Actor | Role |
|---|---|
 Alexis ArquetteGinger (as Eva Destruction) | Ginger (as Eva Destruction) |
| OOmar AlexisCoco | Coco |
| CClark WeaverRoy | Roy |
 Don EdmondsUncle A | Uncle A |
 HajiMoonji | Moonji |
 Lawrence Hilton-JacobsMr. Fly | Mr. Fly |
 Mark BeltzmanAnthony (as Macky Beltzkovsky) | Anthony (as Macky Beltzkovsky) |
 Mario DiazBobby | Bobby |
| RRobbie Lee DowningHat Henchman | Hat Henchman |
| LLeo M. GeorgeYoung Thug | Young Thug |
| DDon LucasRichie | Richie |
| DDr. Robert L. Dean Jr.Old Thug | Old Thug |
| JJames E.L. EselyNot listed | Not listed |
| NNick LuberChan | Chan |
| DDan SteelBruto | Bruto |
| SSven the Swedish PimpSelf | Self |
| WWizzard ElliottBathroom Patron (uncredited) | Bathroom Patron (uncredited) |