Obesity rates in the United States have reached epidemic proportions in recent years. Killer at Large shows how little is being done and more importantly, what can be done to reverse it. Killer at Large also explores the human element of the problem with portions of the film that follow a 12-year old girl who has a controversial liposuction procedure to fix her weight gain and a number of others suffering from obesity, including filmmaker Neil Labute.
| Actor | Role |
|---|---|
 Jim HightowerSelf | Self |
 Tom HarkinSelf (archive footage) | Self (archive footage) |