 Jeremy RennerGary Webb | Gary Webb |
 Mary Elizabeth WinsteadAnna Simons | Anna Simons |
 Michael SheenFred Weil | Fred Weil |
 Ray LiottaJohn Cullen | John Cullen |
 Robert PatrickRonny Quail | Ronny Quail |
 Andy GarciaNorwin Meneses | Norwin Meneses |
 Paz VegaCoral Baca | Coral Baca |
 Michael Kenneth WilliamsRicky Ross | Ricky Ross |
 Rosemarie DeWittSue Webb | Sue Webb |
 Tim Blake NelsonAlan Fenster | Alan Fenster |
 Barry PepperRussell Dodson | Russell Dodson |
 Oliver PlattJerry Ceppos | Jerry Ceppos |
 Richard SchiffRichard Zuckerman | Richard Zuckerman |
 Jena SimsQuail's Girlfriend | Quail's Girlfriend |
 Joshua CloseRich Kline | Rich Kline |
 Yul VazquezDanilo Blandon | Danilo Blandon |
 Lucas HedgesIan Webb | Ian Webb |
 Matt LintzEric Webb | Eric Webb |
 Gil BellowsDEA Agent Miller | DEA Agent Miller |
 Steve CoulterAnonymous Agent | Anonymous Agent |
 Dan FuttermanLeo Wolinsky | Leo Wolinsky |
 Susan WaltersLos Angeles Times Editor | Los Angeles Times Editor |
 David de VriesWashington Post Editor | Washington Post Editor |
 David Lee GarverDoug Farah | Doug Farah |
 Rhoda GriffisFemale Anchor | Female Anchor |
 Jen HarperRicky Ross Trial Judge | Ricky Ross Trial Judge |
 David AlessiDEA Agent (uncredited) | DEA Agent (uncredited) |
| GGrace BaineReporter Washington Post (uncredited) | Reporter Washington Post (uncredited) |
| SShaira BartonDC Business Woman (uncredited) | DC Business Woman (uncredited) |
 Nancy ReaganSelf (archive footage) (uncredited) | Self (archive footage) (uncredited) |
