A village is hounded by an unknown disease, decimating its population. The village priest prophesies that God's avatar will save them. Siddha goes in search of this supernatural potential and finds it in Seetarama Raju, a cab driver.
| Actor | Role |
|---|---|
 Mahesh BabuAlluri Seetarama Raju | Alluri Seetarama Raju |
 ShafiSiddha | Siddha |
 Prakash RajGopala "G.K." Krishnan | Gopala "G.K." Krishnan |
 Rao RameshTantrik | Tantrik |
 Anushka ShettySubhashini | Subhashini |
 AliTom Cruise | Tom Cruise |
 Sunil VarmaBabji | Babji |
 Tanikella BharaniDurga Prasad | Durga Prasad |
 BrahmanandamMiriyam | Miriyam |
 Kota Srinivasa RaoRaju's grandfather | Raju's grandfather |
 SubbarajuGovardhan | Govardhan |
 Raghu BabuSundaram | Sundaram |
| AAman DhaliwalJohn | John |
 Dharmavarupu SubramanyamTaxi Owner | Taxi Owner |
 ArchanaGK's PA | GK's PA |
 Amit Kumar TiwariG.K's Son | G.K's Son |
 Supriya KarnikG.K's Wife | G.K's Wife |
 SudhaG.K's Assistant | G.K's Assistant |
 SriranjiniDevi Prasad's Wife | Devi Prasad's Wife |
 Ananth BabuAnanth | Ananth |
 M. S. NarayanaVillager | Villager |
 Vajja Venkata GiridharA Man | A Man |
 NassarA Person | A Person |
 Gundu SudarshanA Man at a Cafe | A Man at a Cafe |
 Micky MakhijaParanji | Paranji |
 AnnieRevived Girl | Revived Girl |
| SSowmya SharmaSubhashini (Voice) | Subhashini (Voice) |
 Divya Mary CyriacDilawar Singh's wife | Dilawar Singh's wife |