Nate Johnson, a Los Angeles man estranged from his wife and three children, decides to reconnect with his family by taking them with him on a road trip to Missouri for a big family reunion.
| Actor | Role |
|---|---|
 Cedric the EntertainerNate Johnson / Uncle Earl | Nate Johnson / Uncle Earl |
 Vanessa WilliamsDorothy Johnson | Dorothy Johnson |
 SolangeNikki Johnson | Nikki Johnson |
 Shad MossD.J. Johnson | D.J. Johnson |
 Gabby SoleilDestiny Johnson | Destiny Johnson |
 Shannon ElizabethChrishelle Rene Boudreau | Chrishelle Rene Boudreau |
 Steve HarveyMack Johnson | Mack Johnson |
 Aloma WrightGlorietta Johnson | Glorietta Johnson |
 Shari HeadleyJacqueline | Jacqueline |
 Jason MomoaNavarro | Navarro |
 Jennifer FreemanJill | Jill |
 Kat GrahamDancer | Dancer |
 Philip BoldenMack, Jr. | Mack, Jr. |
 GodfreyMotorcycle Cop | Motorcycle Cop |
 Christopher B. DuncanStan | Stan |
 Rodney PerryCousin Lump | Cousin Lump |
 Lorna ScottGladys | Gladys |
 Kevin FarleyStall Guy | Stall Guy |
 Lee GarlingtonBetty Sue | Betty Sue |
 Shane WoodsonAngus | Angus |
 KuruptKurupt | Kurupt |
 Chris HardwickArson Investigator | Arson Investigator |
 Tanjareen MartinTangerine | Tangerine |