A career criminal who has been deformed since birth is given a new face by a kindly doctor and paroled from prison. It appears that he has gone straight, but he is really planning his revenge on the man who killed his mentor and sent him to prison.
| Actor | Role |
|---|---|
 Mickey RourkeJohnny Handsome | Johnny Handsome |
 Ellen BarkinSunny Boyd | Sunny Boyd |
 Morgan FreemanLt. A.Z. Drones | Lt. A.Z. Drones |
 Forest WhitakerDr. Steven Fisher | Dr. Steven Fisher |
 Elizabeth McGovernDonna McCarty | Donna McCarty |
 Lance HenriksenRafe Garrett | Rafe Garrett |
 Scott WilsonMikey Chalmette | Mikey Chalmette |
 David SchrammVic Dumask | Vic Dumask |
 Peter JasonMr. Bonet | Mr. Bonet |
| YYvonne BrycelandSister Luke | Sister Luke |
 Jeffrey MeekEarl | Earl |
 J.W. SmithLarry | Larry |
 Allan GrafBob Lemoyne | Bob Lemoyne |
 Edward WalshJudge | Judge |
| EEugenia IvesNurse | Nurse |
 Blake ClarkSheriff Monte | Sheriff Monte |
 Ken MedlockShipyard Accountant | Shipyard Accountant |
| EEd ZangPrestige Manager | Prestige Manager |
| JJohn P. FertittaPrestige Salesman | Prestige Salesman |
 Raynor ScheineGun Dealer | Gun Dealer |