To teach his sheltered grandson about the real world, Madea's foul-mouthed brother Joe takes the college-bound teen on a raucous cross-country road trip.
| Actor | Role |
|---|---|
 Tyler PerryJoe / Madea / Brian | Joe / Madea / Brian |
 Jermaine HarrisBJ | BJ |
 Amber Reign SmithDestiny | Destiny |
 Bethany Anne LindVikki | Vikki |
 Jeremy GimenezGarrett | Garrett |
 Millie JacksonGeraldine | Geraldine |
 Wil DeusnerStewart | Stewart |
 Patricia WilliamsPearl | Pearl |
 Deetta WestKathryn | Kathryn |
 Shawn Alexander ThompsonNeighbor | Neighbor |
 Ben SwilleyHerbert | Herbert |
 Brian D. CohenTodd | Todd |
| SSierra CevascoAsst. to Brian | Asst. to Brian |
 Shekeb SekanderGangster | Gangster |
| JJust NeshWoman | Woman |
| AAngela L. WilsonLibrarian | Librarian |
 Alexa Blair RobertsonMelanie | Melanie |
 Sandra Lee-Oian ThomasAlice | Alice |
 Jorge A. SanchezBartender | Bartender |
 Dani PaynePolice Officer | Police Officer |
| JJames KinardBand Member | Band Member |
| KKeith JohnsonBand Member | Band Member |
| KKimble FunchessBand Member | Band Member |
| LLester SnellBand Member | Band Member |
| SSteve PottsBand Member | Band Member |
| WWilliam BrownBand Member | Band Member |
 Diane D. CarterOld Lady V.O. (voice) | Old Lady V.O. (voice) |