Joe heads for South America to fight the Latin champ. Shipboard, he helps federal agents fight counterfeiters. He also spars with love interest Anne Howe.
| Actor | Role |
|---|---|
 Leon ErrolKnobby Walsh | Knobby Walsh |
 Joe Kirkwood Jr.Joe Palooka | Joe Palooka |
 Elyse KnoxAnne Howe | Anne Howe |
 Marcel JournetAnton Kindel | Anton Kindel |
 Sheila RyanMyra Madison | Myra Madison |
 Harry LewisChick Bennett | Chick Bennett |
 Frank SullyLooie | Looie |
 Ian WolfeProfessor Lilliquist | Professor Lilliquist |
 Sam HayesFight Announcer | Fight Announcer |
 Walter SandeAustin | Austin |
 Douglass DumbrilleCaptain Lance | Captain Lance |
 Douglas FowleyThurston | Thurston |
 Eddie GribbonCanvasback | Canvasback |
| SSonny ChorreAngelo Cardona | Angelo Cardona |
 Ralph GravesDr. Colman | Dr. Colman |
 Martín GarralagaAnnouncer | Announcer |
 Roland DupreeBellboy | Bellboy |
 Gertrude MessingerNurse | Nurse |
 John HartPedro | Pedro |
 Robert ConwaySteward | Steward |
| JJohn IndrisanoFight Referee | Fight Referee |
| JJoe HerreraFight Referee | Fight Referee |
| RRoy AversaSpanish Handler | Spanish Handler |
| JJohnny CasinoAttendant | Attendant |
 Pedro de CordobaMuseum Caretaker | Museum Caretaker |
 Frank EllisPoliceman | Policeman |
 William RoyMessenger | Messenger |
| PPaul StaderKern | Kern |
| WWally WestArena Policeman | Arena Policeman |