Gangsters frame Joe on a drunk charge and a murder rap so they can put their own fighter into a big event. Joe investigates in an attempt to prove his innocence.
| Actor | Role |
|---|---|
 Leon ErrolKnobby Walsh | Knobby Walsh |
 Joe Kirkwood Jr.Joe Palooka | Joe Palooka |
 Lina RomayMaxine | Maxine |
 David BruceTom Conway | Tom Conway |
 George O'HanlonLouie | Louie |
 Virginia WellesAnne Howe | Anne Howe |
 Greg McClureDutch Grady | Dutch Grady |
 Taylor HolmesDr. Benson | Dr. Benson |
 Ian MacDonaldMike | Mike |
 Lou LubinTalmadge | Talmadge |
| BBert ConwayPee Wee | Pee Wee |
 Lyle TalbotLt. Muldoon | Lt. Muldoon |
 Benny BakerFight Secretary | Fight Secretary |
 Eddie GribbonCanvasback | Canvasback |
| JJack RoperScranton | Scranton |
 Frances OsborneWardrobe Mistress | Wardrobe Mistress |
 Harry HaydenCommissioner Harris | Commissioner Harris |
 Frank FentonDetective | Detective |
| GGeorge FisherBeauty Contest Announcer | Beauty Contest Announcer |
| JJohn IndrisanoReferee | Referee |
| TTed PavelecTiny, a Prizefighter | Tiny, a Prizefighter |