Joanna Angel's Guide 2 Humping documents the experience of a sex seminar hosted by everyone's favorite porn star, Ms. Joanna Angel. The student with the highest score on the final exam is allowed to practice his (or her) new found skills on the teacher. Things take an interesting turn when the class' biggest trouble maker (James Deen) makes the grade....
| Actor | Role |
|---|---|
 Joanna Angelself | self |
 Haley PaigeAna | Ana |
 Kylee Krossinstructional lezbo #1 | instructional lezbo #1 |
 Chapel Wasteinstructional lezbo #2 | instructional lezbo #2 |
 Sierra Sinninstructional kisser | instructional kisser |
 Morgan Maeinstructional anal girl | instructional anal girl |
 James Deenself | self |
 Tommy Pistolself / Gilbert | self / Gilbert |
 Julius Ceazherself | self |
| KKayla Fayteacher's assistant | teacher's assistant |
| PPrince HarlemJamal | Jamal |
| MMike PullenBrad | Brad |
| KKurt KillkennyKurt | Kurt |
| SSammy XAsia | Asia |
| RRay "O" RoyBones | Bones |
| KKimani Rogersmistaken student | mistaken student |
| MMikey Freedominstructional guy #1 | instructional guy #1 |
| DDarien Traininstructional retard | instructional retard |