 Debi DerryberryJimmy Neutron (voice) | Jimmy Neutron (voice) |
 Jeffrey GarciaSheen Estevez (voice) | Sheen Estevez (voice) |
 Rob PaulsenCarl Wheezer (voice) | Carl Wheezer (voice) |
 Mark DeCarloHugh Neutron (voice) | Hugh Neutron (voice) |
 Carolyn LawrenceCindy Vortex (voice) | Cindy Vortex (voice) |
 Frank WelkerGoddard (voice) | Goddard (voice) |
 Crystal ScalesLibby Fallfax (voice) | Libby Fallfax (voice) |
 Megan CavanaghJudy Neutron (voice) | Judy Neutron (voice) |
 Charlie AdlerJunkman (voice) | Junkman (voice) |
 Jeff BennettTravoltron (voice) | Travoltron (voice) |
 S. Scott BullockKing Goobot (voice) | King Goobot (voice) |
 Tim CurryProfessor Calamitous(voice) | Professor Calamitous(voice) |
 Paul GreenbergBrobot (voice) | Brobot (voice) |
 Maurice LaMarcheZia (voice) | Zia (voice) |
 Wendie MalickBeautiful Gorgeous (voice) | Beautiful Gorgeous (voice) |
 Andrea MartinMs. Fowl (voice) | Ms. Fowl (voice) |
 Edie McClurgGrandma Taters (voice) | Grandma Taters (voice) |
 Candi MiloNick Dean (voice) | Nick Dean (voice) |
 Kevin Michael RichardsonTee (voice) | Tee (voice) |
 Billy WestSam Melnick (voice) | Sam Melnick (voice) |