At the age of ten, Henry James Hermin, a boy who was conceived in a petri-dish and raised by his feminist mother, follows a string of Post-It notes in hopes of finding his biological father.
| Actor | Role |
|---|---|
 Michael SheenDr. Slavkin O'Hara | Dr. Slavkin O'Hara |
 Toni CollettePatricia Herman | Patricia Herman |
 Jason SpevackHenry James Herman | Henry James Herman |
 Samantha WeinsteinAudrey O'Hara | Audrey O'Hara |
 Melyssa AdeKindergarten Teacher | Kindergarten Teacher |
 Oprah WinfreyOprah | Oprah |
 Frank MooreStan Herman | Stan Herman |
 Paul BraunsteinDr. Gunther Flowers | Dr. Gunther Flowers |
| HHannah BrigdenYoung Patricia Herman | Young Patricia Herman |
 Sarah OrensteinMother Herman | Mother Herman |
 Jamie JohnstonYoung Billy Herman | Young Billy Herman |
 Mark MacDonaldTim Herman | Tim Herman |
 Mickey MacDonaldTom Herman | Tom Herman |
 Cameron KennedyJimmy Herman | Jimmy Herman |
 Kate HewlettAlice O'Hara | Alice O'Hara |
 Kevin HareDelivery Room Doctor | Delivery Room Doctor |
 Austin MacdonaldBrian the Bully | Brian the Bully |
 Mishu VellaniMiss Abda | Miss Abda |
 Aaron AbramsMalcom's Dad / Nurse Stewart | Malcom's Dad / Nurse Stewart |