Jennifer, a gorgeous, seductive cheerleader takes evil to a whole new level after she's possessed by a sinister demon. Now it's up to her best friend to stop Jennifer's reign of terror before it's too late.
| Actor | Role |
|---|---|
 Megan FoxJennifer | Jennifer |
 Amanda SeyfriedNeedy | Needy |
 Johnny SimmonsChip | Chip |
 Adam BrodyNikolai | Nikolai |
| SSal CortezChas | Chas |
| RRyan LevineMick | Mick |
 Juan RiedingerDirk | Dirk |
| CColin AskeyKeyboardist | Keyboardist |
 Chris PrattRoman Duda | Roman Duda |
 Juno RinaldiOfficer Warzak | Officer Warzak |
 Kyle GallnerColin Gray | Colin Gray |
 Josh EmersonJonas Kozelle | Jonas Kozelle |
 J.K. SimmonsMr. Wroblewski | Mr. Wroblewski |
 Amy SedarisNeedy's Mom | Needy's Mom |
 Cynthia StevensonChip's Mom | Chip's Mom |
 Nicole LeducCamille | Camille |
| AAman JohalAhmet from India | Ahmet from India |
 Dan JoffreRaymundo | Raymundo |
 Candus ChurchillNutritionist | Nutritionist |
 Carrie GenzelJennifer's Mom | Jennifer's Mom |
| EEmma GallelloLittle Jennifer | Little Jennifer |
 Megan CharpentierLittle Needy | Little Needy |
 Jeremy SchuetzeCraig | Craig |
| VValerie TianChastity | Chastity |
 Emily TennantGossiping Girl | Gossiping Girl |
 Karissa TynesOther Girl | Other Girl |
 Eve HarlowGoth Girl | Goth Girl |
| MMichael BrockGoth Boy | Goth Boy |
 Genevieve BuechnerGoth Girl #2 | Goth Girl #2 |
 Adrian HoughColin's Dad | Colin's Dad |