This turn-of-the-century tragedy chronicles the sorrowful travails of a woman who endures a series of devastating losses.
| Actor | Role |
|---|---|
 Sylvia SidneyJennie Gerhardt | Jennie Gerhardt |
 Donald CookLester Kane | Lester Kane |
 Mary AstorLetty Pace | Letty Pace |
 Edward ArnoldSen. Brander | Sen. Brander |
 H.B. WarnerWilliam Gerhardt | William Gerhardt |
 Theodore von EltzRobert Kane | Robert Kane |
 Dorothy LibaireLouise Kane | Louise Kane |
 Louise CarterMrs. Gerhardt | Mrs. Gerhardt |
 Jane DarwellBoardinghouse Keeper (uncredited) | Boardinghouse Keeper (uncredited) |
 Frank ReicherOld Weaver (uncredited) | Old Weaver (uncredited) |
 Betsy Ann HisleVeronica Gerhardt (uncredited) | Veronica Gerhardt (uncredited) |
 Edward LeSaintLester's Doctor (uncredited) | Lester's Doctor (uncredited) |
 Morgan WallaceO'Brien (uncredited) | O'Brien (uncredited) |
 Cora Sue CollinsVesta at Age 6 | Vesta at Age 6 |