 Laura San GiacomoJenifer Estess | Jenifer Estess |
 Jane KaczmarekValerie Estess | Valerie Estess |
 Annabella SciorraMeredith Estess | Meredith Estess |
 Jane AlexanderMarilyn Estess | Marilyn Estess |
 Maddie CormanJulianne Hoffenberg | Julianne Hoffenberg |
 Edie FalcoWheelchair Saleswoman | Wheelchair Saleswoman |
 Donna HanoverHerself | Herself |
 Camryn ManheimNurse Vandemal | Nurse Vandemal |
 Julianna MarguliesJenifer's Psychiatrist | Jenifer's Psychiatrist |
 Rob MorrowDr. Richard Feldman | Dr. Richard Feldman |
 Reed RudyScotty | Scotty |
 Cedric SmithDr. Richards | Dr. Richards |
 Vincent SpanoJack | Jack |
 Fisher StevensDr. Aaron Sanders | Dr. Aaron Sanders |
 Marisa TomeiNina Capelli | Nina Capelli |
 Bradley WhiteMichael | Michael |
 Scott WolfJenifer's Date | Jenifer's Date |
 Colin FergusonPeter | Peter |
 Karen RobinsonLorna | Lorna |
 Jason BlickerNeurologist | Neurologist |
 Robert BockstaelResearcher | Researcher |
| SSarah BolstridgeJenifer (Age 12) | Jenifer (Age 12) |
 Christopher BondyJenifer's Father (as Chris Bondy) | Jenifer's Father (as Chris Bondy) |
 Johnie ChaseBus Driver | Bus Driver |
 David EisnerImpatient Passenger | Impatient Passenger |
| AAlex GaistmanJane (Age 3) | Jane (Age 3) |
 Imogen HaworthValerie (Age 14) | Valerie (Age 14) |
| DDanny MagsJake (age 6) | Jake (age 6) |
| MMallory MargelMeredith (Age 11) | Meredith (Age 11) |
| JJim McAleeseFire Marshal | Fire Marshal |