 Jenifer LewisJackie Washington | Jackie Washington |
 Tim CurryEdward Whatsett St. John | Edward Whatsett St. John |
 T.V. BlakeAntandra Washington (Jackie's Daughter) | Antandra Washington (Jackie's Daughter) |
 Tangie AmbroseShaniqua Summers Wells (Jackie's Daughter) | Shaniqua Summers Wells (Jackie's Daughter) |
 Whoopi GoldbergNurse Ethyl Washington Rue Owens (Jackie's Sister) | Nurse Ethyl Washington Rue Owens (Jackie's Sister) |
 Robert Bailey Jr.Wilson Wells (Jackie's Grandson) | Wilson Wells (Jackie's Grandson) |
 Tom ArnoldMarvin Pritz (Jackie's Former Manager) | Marvin Pritz (Jackie's Former Manager) |
 Loretta DevineSnookie Tate (Jackie's Childhood Friend) | Snookie Tate (Jackie's Childhood Friend) |
 Julie HagertyPammy Dunbar (Infomercial Host) | Pammy Dunbar (Infomercial Host) |
 David Hyde PiercePerry (The Deaf Rehearsal Pianist) | Perry (The Deaf Rehearsal Pianist) |
 Kathy NajimyLola Molina (Jackie's Stalker) | Lola Molina (Jackie's Stalker) |
 Isabel SanfordMiss Krumes (Jackie's Play Mama) | Miss Krumes (Jackie's Play Mama) |
 JoBeth WilliamsJo Face (Jackie's Vocal Coach) | Jo Face (Jackie's Vocal Coach) |
 Mary WilsonVesta Crotchley (Jackie's Third Grade Teacher) | Vesta Crotchley (Jackie's Third Grade Teacher) |
 Reynaldo ReyCadillac Johnson (Retired Pimp) | Cadillac Johnson (Retired Pimp) |
 Loren FreemanKim (Jackie's Costume Designer) | Kim (Jackie's Costume Designer) |
| DDerrick JonesPeaches Yancy (Still Photos) | Peaches Yancy (Still Photos) |
 Richard LawsonMilkman Summers (Jackie's Ex-Husband #1) | Milkman Summers (Jackie's Ex-Husband #1) |
 Patti AustinPatti Austin (Gospel Singer at Peaches' Funeral) | Patti Austin (Gospel Singer at Peaches' Funeral) |
 Kyla PrattLittle Jackie Washington | Little Jackie Washington |
| LLori HarmonAngela Scotorcio (Body Double) | Angela Scotorcio (Body Double) |
| JJohnny BrownRev. Eustace Barnett (Pastor, Kinloch Baptist Temple) | Rev. Eustace Barnett (Pastor, Kinloch Baptist Temple) |
 Alan BlumenfeldIvan (Theatre Manager) | Ivan (Theatre Manager) |
 Charles BarkleyCharles Barkley | Charles Barkley |
 Diahann CarrollDiahann Carroll | Diahann Carroll |
 Eddie CibrianEddie Cibrian | Eddie Cibrian |
 Jackie CollinsJackie Collins | Jackie Collins |
 Don CorneliusDon Cornelius | Don Cornelius |
 Taylor DayneTaylor Dayne | Taylor Dayne |
 Melissa EtheridgeMelissa Etheridge | Melissa Etheridge |
