An art dealer on a special mission is pulled into dangerous intrigue while railway detective Cheval tries to help and pursues criminals on the Istanbul Express.
| Actor | Role |
|---|---|
 Gene BarryMichael London | Michael London |
 John SaxonCheval | Cheval |
 Senta BergerMila Darvos | Mila Darvos |
 Tom SimcoxLeland McCord | Leland McCord |
 Mary Ann MobleyPeggy Coopersmith | Peggy Coopersmith |
 Werner PetersDr. Lenz | Dr. Lenz |
 Donald WoodsShepherd | Shepherd |
 Jack KruschenCapt. Granicek | Capt. Granicek |
 John MarleyKapel | Kapel |
 Philip BourneufClaude | Claude |
 Norma VardenEnglishwoman | Englishwoman |
 Émile GenestHenri the Conductor | Henri the Conductor |
 MoustacheGustav | Gustav |
 Allen JaffeDr. Lenz's Henchman | Dr. Lenz's Henchman |