 Bryan CranstonChief (voice) | Chief (voice) |
 Koyu RankinAtari Kobayashi (voice) | Atari Kobayashi (voice) |
 Bob BalabanKing (voice) | King (voice) |
 Edward NortonRex (voice) | Rex (voice) |
 Bill MurrayBoss (voice) | Boss (voice) |
 Jeff GoldblumDuke (voice) | Duke (voice) |
 Kunichi NomuraMayor Kobayashi (voice) | Mayor Kobayashi (voice) |
 Fisher StevensScrap (voice) | Scrap (voice) |
 Akira TakayamaMajor Domo (voice) | Major Domo (voice) |
 Greta GerwigTracy Walker (voice) | Tracy Walker (voice) |
 Ken WatanabeHead Surgeon (voice) | Head Surgeon (voice) |
 Frances McDormandInterpreter Nelson (voice) | Interpreter Nelson (voice) |
 Nijiro MurakamiEditor Hiroshi (voice) | Editor Hiroshi (voice) |
 Harvey KeitelGondo (voice) | Gondo (voice) |
 Liev SchreiberSpots (voice) | Spots (voice) |
 Scarlett JohanssonNutmeg (voice) | Nutmeg (voice) |
 Tilda SwintonOracle (voice) | Oracle (voice) |
| AAkira ItoProfessor Watanabe (voice) | Professor Watanabe (voice) |
 F. Murray AbrahamJupiter (voice) | Jupiter (voice) |
 Courtney B. VanceNarrator (voice) | Narrator (voice) |
 Yoko OnoAssistant-Scientist Yoko-ono (voice) | Assistant-Scientist Yoko-ono (voice) |
 Mari NatsukiAuntie (voice) | Auntie (voice) |
 Yojiro NodaNews Anchor (voice) | News Anchor (voice) |
 Frank WoodSimul-Translate Machine (voice) | Simul-Translate Machine (voice) |
 Roman CoppolaIgor (voice) | Igor (voice) |
 Anjelica HustonMute Poodle (voice) | Mute Poodle (voice) |
 Kara HaywardPeppermint (voice) | Peppermint (voice) |
| SSatoshi YamazakiTaiko Drummer (voice) | Taiko Drummer (voice) |
| GGen UedaTaiko Drummer (voice) | Taiko Drummer (voice) |
 Ryuhei MatsudaJunior Scientist 4 / Bartender (voice) | Junior Scientist 4 / Bartender (voice) |
