 Mark FischbachSimon | Simon |
 Caroline KaplanAva | Ava |
 Troy BakerDavid | David |
 Elsie LovelockSM-8 Research Lead / The Speaker (voice) | SM-8 Research Lead / The Speaker (voice) |
 Elle LaMontSM-8 Research Assistant / The Whisper (voice) | SM-8 Research Assistant / The Whisper (voice) |
 Mick LauerThe Guy Who Told You to Cross the Wires (voice) | The Guy Who Told You to Cross the Wires (voice) |
 Dave PettittThe Father | The Father |
 Holt BoggsEden Soldier | Eden Soldier |
 Isaac McKeeYoung Simon | Young Simon |
| RRoman Parsons CrowChild of Eden | Child of Eden |
| RRiver Van Coleman CrowChild of Eden | Child of Eden |
| TTownes Blaine CrowChild of Eden | Child of Eden |
 Asher WaghChild of Eden | Child of Eden |
 Kazuki JalalChild of Eden | Child of Eden |
 Alanah PearceA Familiar Voice (voice) | A Familiar Voice (voice) |
 Seán McLoughlinJack | Jack |
 David SzymanskiDavid Szymanski | David Szymanski |
 Danielle Evon PloegerTow Ship Pilot | Tow Ship Pilot |
 Rahul KohliAdditional Voices (voice) | Additional Voices (voice) |
 Ethan NestorAdditional Voices (voice) | Additional Voices (voice) |
 ValkyraeAdditional Voices (voice) | Additional Voices (voice) |
 Mika MidgettAdditional Voices (voice) | Additional Voices (voice) |
 Robert RexxAdditional Voices (voice) (uncredited) | Additional Voices (voice) (uncredited) |
