The adventures of a group of explorers who make use of a newly discovered wormhole to surpass the limitations on human space travel and conquer the vast distances involved in an interstellar voyage.
| Actor | Role |
|---|---|
 Matthew McConaugheyCooper | Cooper |
 Anne HathawayBrand | Brand |
 Michael CaineProfessor Brand | Professor Brand |
 Jessica ChastainMurph | Murph |
 Casey AffleckTom | Tom |
 Wes BentleyDoyle | Doyle |
 Topher GraceGetty | Getty |
 Mackenzie FoyMurph (10 Yrs.) | Murph (10 Yrs.) |
 Ellen BurstynMurph (older) | Murph (older) |
 John LithgowDonald | Donald |
 Bill IrwinTARS (voice) | TARS (voice) |
 David GyasiRomilly | Romilly |
 Timothée ChalametTom (15 Yrs.) | Tom (15 Yrs.) |
 Matt DamonMann | Mann |
 Josh StewartCASE (voice) | CASE (voice) |
 Leah CairnsLois | Lois |
 Liam DickinsonCoop | Coop |
 Francis X. McCarthyBoots | Boots |
 William DevaneWilliams | Williams |
 Andrew BorbaSmith | Smith |
 Elyes GabelAdministrator | Administrator |
 David OyelowoSchool Principal | School Principal |
 Collette WolfeMs. Hanley | Ms. Hanley |
 Jeff HephnerDoctor | Doctor |
 Russ FegaCrew Chief | Crew Chief |
 Lena GeorgasNurse Practitioner | Nurse Practitioner |
 Brooke SmithNurse | Nurse |
 Flora NolanGirl on Truck | Girl on Truck |
| GGriffen FraserBoy on Truck | Boy on Truck |
 Kristian Van der HeydenScientist (uncredited) | Scientist (uncredited) |