| AAlex MurdaughSelf | Self |
| CCraig MoyerSelf - Juror | Self - Juror |
 Lester HoltSelf (archive footage) | Self (archive footage) |
 Norah O'DonnellSelf (archive footage) | Self (archive footage) |
 David MuirSelf (archive footage) | Self (archive footage) |
 Dana BashSelf (archive footage) | Self (archive footage) |
| JJoe McCullochSelf - Lawyer | Self - Lawyer |
| MMyra CrosbySelf - Juror | Self - Juror |
| BBecky HillSelf - Colleton County Clerk of Court (archive footage) | Self - Colleton County Clerk of Court (archive footage) |
| BBuster MurdaughSelf (archive footage) | Self (archive footage) |
| CClifton NewmanSelf - Judge (archive footage) | Self - Judge (archive footage) |
| JJean ToalSelf - Judge (archive footage) | Self - Judge (archive footage) |
| MMelissa GordonSelf - Co-Creator, Trial Watchers | Self - Co-Creator, Trial Watchers |
| NNeil GordonSelf - Co-Creator, Trial Watchers | Self - Co-Creator, Trial Watchers |
| AAlan WilsonSelf - South Carolina Attorney General | Self - South Carolina Attorney General |
| JJames M. GriffinSelf - Alex Murdaugh's Attorney | Self - Alex Murdaugh's Attorney |
| DDick HarpootlianSelf - Alex Murdaugh's Attorney | Self - Alex Murdaugh's Attorney |
