 Kate McKinnonCoakley | Coakley |
 Rashida JonesClaire | Claire |
 Daveed DiggsGreg | Greg |
 Jorge VargasNeanderthal Father - Thorn | Neanderthal Father - Thorn |
 Tanaya BeattyNeanderthal Mother - Hera | Neanderthal Mother - Hera |
 Skywalker HughesNeanderthal Daughter - Lark | Neanderthal Daughter - Lark |
 Rhona ReesROSCO (voice) | ROSCO (voice) |
 Tatyana Rose BaptisteNeanderthal Daughter - Adult Lark | Neanderthal Daughter - Adult Lark |
| NNox WatkinsNeanderthal Son - Lucky | Neanderthal Son - Lucky |
| TTyson NightNeanderthal Son - Adult Lucky | Neanderthal Son - Adult Lucky |
 Luc RoderiqueDavid | David |
 Andrea BangV | V |
 Diana TsoyV (12 Years Old) | V (12 Years Old) |
| AAria KimV (7 Years Old) | V (7 Years Old) |
 Yeji KimV (5 Years Old) | V (5 Years Old) |
 Cameron RobertsHunter | Hunter |
| TTheodore StarrVillage Elder | Village Elder |
 Karin KonovalClaire's Mom | Claire's Mom |
| GGui FontanezziSasha | Sasha |
 Lydia CampbellJess | Jess |
| TTyler PetersLark's Son (6–7 Years Old) | Lark's Son (6–7 Years Old) |
 Maggie MaChemo Nurse | Chemo Nurse |
 Taylor KinequonShishi (Adult) | Shishi (Adult) |
 Moses WamukoyaOtto (Adult) | Otto (Adult) |
| MMayson MarshallShishi (8 Years Old) | Shishi (8 Years Old) |
 Milah ThompsonGirl at Museum | Girl at Museum |
| AAthan IrinakisKid at Museum | Kid at Museum |
 Olivia Ryan SternDave's Daughter | Dave's Daughter |
| EEli KingDavid (8 Years Old) | David (8 Years Old) |
 Haig SutherlandDocent | Docent |
