I'm Coming Over reveals a day in the life of Matt Downing, owner and proprietor of I’m Coming Over, specializing in holistic happiness. When traditional therapy has failed, Matt Downing picks up the pieces with common sense, good old fashioned hard work, and a strict avoidance of the modern world.
| Actor | Role |
|---|---|
 Josh HamiltonMatt Downing | Matt Downing |
 Lauren AmbroseGreta | Greta |
 Mike BirbigliaTom Moore | Tom Moore |
 Scott CohenWerner | Werner |
 Brian KlugmanTodd Trumball | Todd Trumball |
 Hamish LinklaterBuffalo | Buffalo |
 Ron McLartyTerry | Terry |
 Joanne TuckerCathy Avery | Cathy Avery |
 Adam DriverEvan | Evan |
 Erica NewhouseJulie | Julie |
| JJoe BurkeJoe | Joe |
| JJulie WebsterDebbie | Debbie |
| MMatt DowningOtis | Otis |
| EEvan PalazzoKip | Kip |
 Jay O. SandersWalter | Walter |
| LLukas SchwartzLucas | Lucas |