 Ray RomanoManny (voice) | Manny (voice) |
 John LeguizamoSid (voice) | Sid (voice) |
 Denis LearyDiego (voice) | Diego (voice) |
 Simon PeggBuck (voice) | Buck (voice) |
 Seann William ScottCrash (voice) | Crash (voice) |
 Josh PeckEddie (voice) | Eddie (voice) |
 Queen LatifahEllie (voice) | Ellie (voice) |
 Bill HaderGazelle (voice) | Gazelle (voice) |
 Kristen WiigPudgy Beaver Mom (voice) | Pudgy Beaver Mom (voice) |
 Chris WedgeScrat (voice) | Scrat (voice) |
 Karen DisherScratte (voice) | Scratte (voice) |
| EEunice ChoMadison (Diatryma Girl) (voice) | Madison (Diatryma Girl) (voice) |
 Maile FlanaganAardvark Mom (voice) | Aardvark Mom (voice) |
 Jason FricchioneAdult Molehog Male (voice) | Adult Molehog Male (voice) |
 Harrison FahnGlypto Boy (voice) | Glypto Boy (voice) |
 Kelly KeatonMolehog Mom / Shovelmouth Mom (voice) | Molehog Mom / Shovelmouth Mom (voice) |
 Joey KingBeaver Girl (voice) | Beaver Girl (voice) |
| LLucas LeguizamoAardvark Boy / Beaver Kid #2 (voice) | Aardvark Boy / Beaver Kid #2 (voice) |
 Jane LynchDiatryma Mom (voice) | Diatryma Mom (voice) |
| RRegan MizrahiAdditional voices / ADR Group | Additional voices / ADR Group |
 Clea LewisStart Mom (voice) | Start Mom (voice) |
 Allegra LeguizamoAardvark Girl (voice) | Aardvark Girl (voice) |
 Carlos SaldanhaDinosaur Babies / Flightless Bird (voice) | Dinosaur Babies / Flightless Bird (voice) |
 Claudia BessoAdditional Voice (voice) | Additional Voice (voice) |
 Bea MillerAdditional Voice / ADR Group (voice) | Additional Voice / ADR Group (voice) |
| CChristian PikesLittle Johnny (Aardvark Kid) (voice) | Little Johnny (Aardvark Kid) (voice) |
| AAvery Christopher PlumBeaver Kid #1 (voice) | Beaver Kid #1 (voice) |
 Joseph RomanoRonald (Shovelmouth Boy) (voice) | Ronald (Shovelmouth Boy) (voice) |
| MManoela Scarpa SaldanhaMolehog Girl 1 (voice) | Molehog Girl 1 (voice) |
 Sofia Scarpa SaldanhaMolehog Girl 2 (voice) | Molehog Girl 2 (voice) |
