Living in the slums, Lupe carries her disabled mother while begging outside the Manila Cathedral, before leveraging her singing talent to escape poverty and rise to stardom.
| Actor | Role |
|---|---|
 Sharon CunetaLupe Velez | Lupe Velez |
 Tonton GutierrezCarding | Carding |
| LLoretta MarquezMetring | Metring |
 Rey "PJ" AbellanaTony | Tony |
 Mark GilGreco | Greco |
 Princess PunzalanLuming | Luming |
 Mario MontenegroDon Ignacio | Don Ignacio |
 Anita LindaMomay | Momay |
 Raul AragonKadyo | Kadyo |
 Deborah SunBunny | Bunny |
| MMarilen MartinezRuffy | Ruffy |
| JJimmy ReyesNot listed | Not listed |
 Joey LunaNot listed | Not listed |
| EEstrella AntonioNot listed | Not listed |
| BBebot DavaoNot listed | Not listed |
 Josie TagleNot listed | Not listed |
| JJoseph MillerNot listed | Not listed |
| VVic TagleNot listed | Not listed |
| WWencel de GuzmanNot listed | Not listed |