Semiramis, a powerful and beautiful Assyrian queen, oversees the construction of the luxurious city of Babylon. She falls in love with Kir, a fallen prince turned into a slave who corresponds to her love. But a palace conspiracy will make the two lovers separate and confront each other.
| Actor | Role |
|---|---|
 Yvonne FurneauxSemiramis | Semiramis |
 John EricsonKir | Kir |
 Renzo RicciMinurte | Minurte |
 Gianni RizzoGhelas | Ghelas |
 Germano LongoOmnos | Omnos |
 John BarthaAlthar | Althar |
| NNino Di NapoliAdath - The King's Son | Adath - The King's Son |
| VValérie CamilleDancer | Dancer |
 Mario LaurentinoOerte | Oerte |
| PPiero PastoreShabli | Shabli |
 Mario PassanteNaval Constructor | Naval Constructor |
 Ugo SassoOmnos' Officer | Omnos' Officer |
 Annamaria UbaldiMaid | Maid |
| HHarold BradleySlave | Slave |
| AAntonio CoreviZagros | Zagros |
 Lucio De SantisMarduk | Marduk |
 Charles FawcettHigh Priest | High Priest |
 Massimo GiulianiAdarte | Adarte |
| UUmberto SilvestriWrestler | Wrestler |
 José TorresPharaoh's Messenger | Pharaoh's Messenger |
 Aldo VascoWrestler | Wrestler |