The encounters of two people who run into each other on several occasions under circumstances ranging from friendly to hostile to loving. Along many years and countless run-ins, the two despise each other, befriend each other, and fall in love with each other—in no particular order.
| Actor | Role |
|---|---|
 Rani MukerjiRhea Prakash | Rhea Prakash |
 Saif Ali KhanKaran Kapoor | Karan Kapoor |
 Kirron KherParminder Prakash | Parminder Prakash |
 Rati AgnihotriAnju Kapoor | Anju Kapoor |
 Rishi KapoorArjun Kapoor | Arjun Kapoor |
 Jimmy ShergillMihir Vora | Mihir Vora |
 Abhishek BachchanSameer | Sameer |
 Shenaz TreasuryShalini | Shalini |
 Isha KoppikarDiana Fernandez | Diana Fernandez |
 Parinita SethFriend | Friend |