 Adam SandlerCount Dracula (voice) | Count Dracula (voice) |
 Kathryn HahnEricka Van Helsing (voice) | Ericka Van Helsing (voice) |
 Selena GomezMavis Dracula (voice) | Mavis Dracula (voice) |
 Jim GaffiganProfessor Abraham Van Helsing (voice) | Professor Abraham Van Helsing (voice) |
 Andy SambergJohnny Loughran (voice) | Johnny Loughran (voice) |
 Kevin JamesFrankenstein (voice) | Frankenstein (voice) |
 Fran DrescherEunice (voice) | Eunice (voice) |
 Steve BuscemiWayne (voice) | Wayne (voice) |
 Molly ShannonWanda (voice) | Wanda (voice) |
 David SpadeGriffin (voice) | Griffin (voice) |
 Keegan-Michael KeyMurray (voice) | Murray (voice) |
 Asher BlinkoffDennis Loughran (voice) | Dennis Loughran (voice) |
 Chris ParnellStan / Fish Man (voice) | Stan / Fish Man (voice) |
 Joe JonasThe Kraken (voice) | The Kraken (voice) |
 Chrissy TeigenCrystal (voice) | Crystal (voice) |
 Mel BrooksVlad (voice) | Vlad (voice) |
 Aaron LaPlanteGremlins / Gremlin Pilot / Gremlin Stewardess (voice) | Gremlins / Gremlin Pilot / Gremlin Stewardess (voice) |
 Michelle MurdoccaPhone / Kelsey / Witch #1 / Witch #2 (voice) | Phone / Kelsey / Witch #1 / Witch #2 (voice) |
 Genndy TartakovskyBlobby / Blobby Baby / Puppy Blobby (voice) | Blobby / Blobby Baby / Puppy Blobby (voice) |
 Joyce ArrastiaZingr Witch / Witch #3 (voice) | Zingr Witch / Witch #3 (voice) |
 Sadie SandlerWinnie (voice) | Winnie (voice) |
 Sunny SandlerSunny (voice) | Sunny (voice) |
 Tara StrongFrankenlady (voice) | Frankenlady (voice) |
| LLibby Thomas DickeyLucy (voice) | Lucy (voice) |
| PPatrick HarpinAustrian Boy (voice) | Austrian Boy (voice) |
 Craig KellmanMr. Hydraberg (voice) | Mr. Hydraberg (voice) |
 Joe WhyteTinkles / Bob (voice) | Tinkles / Bob (voice) |
 Jaime CamilChupacabra (voice) | Chupacabra (voice) |
 Fred TatascioreAdditional Voices (voice) | Additional Voices (voice) |
 Kari WahlgrenAdditional Voices (voice) | Additional Voices (voice) |
