In the spring of 1903, on a whim and a fifty-dollar bet, Dr. Horatio Nelson Jackson set off from San Francisco in a 20-horsepower Winton touring car hoping to become the first person to cross the United States in the new-fangled "horseless carriage." Most people doubted that the automobile had much of a future. Jackson's trip would prove them wrong.
| Actor | Role |
|---|---|
 Tom HanksHoratio Nelson Jackson (voice) | Horatio Nelson Jackson (voice) |
 Keith DavidNarrator (voice) | Narrator (voice) |
 Adam ArkinOther Voices (voice) | Other Voices (voice) |
 Philip BoscoOther Voices (voice) | Other Voices (voice) |
 John CullumOther Voices (voice) | Other Voices (voice) |
 Amy MadiganOther Voices (voice) | Other Voices (voice) |
 Eli WallachOther Voices (voice) | Other Voices (voice) |