E.B., the Easter Bunny's teenage son, heads to Hollywood, determined to become a drummer in a rock 'n' roll band. In L.A., he's taken in by Fred after the out-of-work slacker hits E.B. with his car.
| Actor | Role |
|---|---|
 Russell BrandE.B (voice) | E.B (voice) |
 James MarsdenFred | Fred |
 Kaley CuocoSamantha O'Hare | Samantha O'Hare |
 Hank AzariaCarlos / Phil (voice) | Carlos / Phil (voice) |
 Elizabeth PerkinsBonnie O'Hare | Bonnie O'Hare |
 Gary ColeHenry O'Hare | Henry O'Hare |
 Hugh LaurieE.B.'s Dad (voice) | E.B.'s Dad (voice) |
 David HasselhoffDavid Hasselhoff | David Hasselhoff |
 Chelsea HandlerMrs. Beck | Mrs. Beck |
 Dustin YbarraCody | Cody |
 Tiffany EspensenAlex O'Hare | Alex O'Hare |
| JJimmy CarterBlind Boys of Alabama | Blind Boys of Alabama |
 Veronica AlicinoWaitress | Waitress |
 Coleton RayYoung Fred | Young Fred |
 Mark RiccardiSecurity Guard | Security Guard |
 Greg LewisPerformer | Performer |
 Hugh HefnerVoice at Playboy Mansion (voice) | Voice at Playboy Mansion (voice) |
 Rick PasqualoneUtility Voice | Utility Voice |
 Django MarshYoung E.B. (voice) | Young E.B. (voice) |
 Robbie TuckerKid#1 (uncredited) | Kid#1 (uncredited) |
 Crystal the MonkeyMonkey (uncredited) | Monkey (uncredited) |