John Russell, disdained by his "respectable" fellow stagecoach passengers because he was raised by Indians, becomes their only hope for survival when they are set upon by outlaws.
| Actor | Role |
|---|---|
 Paul NewmanJohn Russell | John Russell |
 Fredric MarchDr. Alex Favor | Dr. Alex Favor |
 Richard BooneCicero Grimes | Cicero Grimes |
 Diane CilentoJessie | Jessie |
 Cameron MitchellFrank Braden | Frank Braden |
 Barbara RushAudra Favor | Audra Favor |
 Peter LazerBilly Lee Blake | Billy Lee Blake |
 Margaret BlyeDoris Blake | Doris Blake |
 Martin BalsamHenry Mendez | Henry Mendez |
 Skip WardSteve Early | Steve Early |
 Frank SilveraMexican Bandit | Mexican Bandit |
 David CanaryLamar Dean | Lamar Dean |
 Val AveryDelgado | Delgado |
 Larry WardSoldier | Soldier |
| LLinda CordovaMrs. Delgado (uncredited) | Mrs. Delgado (uncredited) |
| PPete HernandezApache (uncredited) | Apache (uncredited) |
| MMerrill C. IsbellApache (uncredited) | Apache (uncredited) |