Comedian Lewis Black presents a "history of the joke" while trying to find the greatest joke ever told.
| Actor | Role |
|---|---|
 Lewis BlackHost | Host |
 Dave AttellSelf | Self |
 George CarlinSelf | Self |
 Kathy GriffinSelf | Self |
 Patton OswaltSelf | Self |
 Brian PosehnSelf | Self |
 Iliza ShlesingerSelf | Self |
 Penn JilletteSelf | Self |
 TellerSelf | Self |
 Aisha TylerSelf | Self |
 Kathleen MadiganSelf | Self |
 Jeff DunhamSelf | Self |
 Mitch FatelSelf | Self |
 Robin WilliamsSelf | Self |
 GallagherSelf | Self |