Higurashi Outbreak is set in the same Hinamizawa village of the previous stories. The village has been completely sealed off due to a mysterious virus in 1983, and Keiichi Maebara and Rena Ryūgū deal with the outbreak. But this time, they don't know if its Oyashiro-sama's curse or a conspiracy. It is also shown that Rika might be infected by the virus. Not much is known about the story yet, but in an interview the makers of the OVA revealed that the ending will differ from the original story.
| Actor | Role |
|---|---|
 Mika KanaiSatoko Houjou (voice) | Satoko Houjou (voice) |
 Mai NakaharaRena Ryuuguu (voice) | Rena Ryuuguu (voice) |
 Soichiro HoshiKeiichi Maebara (voice) | Keiichi Maebara (voice) |
 Yukari TamuraRika Furude (voice) | Rika Furude (voice) |
 Satsuki YukinoMion Sonozaki (voice) | Mion Sonozaki (voice) |
| Satsuki YukinoShion Sonozaki (voice) | Shion Sonozaki (voice) |
 Yui HorieHanyuu Furude (voice) | Hanyuu Furude (voice) |
 Rie TanakaNomura (voice) | Nomura (voice) |
 Toshihiko SekiKyousuke Irie (voice) | Kyousuke Irie (voice) |
 Naoko MatsuiAiko Maebara (voice) | Aiko Maebara (voice) |
 Yasunori MatsumotoIchirou Maebara (voice) | Ichirou Maebara (voice) |