Charlie, a wise-cracking, homeless, American orphan is magically transported to the ancient Chinese kingdom of Sanxingdui, where a colorful team of superheroes need his help to defend the city from a brutal conqueror. Charlie joins the heroes, and secretly schemes to steal the priceless golden masks that grant them their powers.
| Actor | Role |
|---|---|
 Ron PerlmanKunyi (voice) | Kunyi (voice) |
 Natasha Liu BordizzoLi (voice) | Li (voice) |
 Patton OswaltAesop (voice) | Aesop (voice) |
 Christopher PlummerRizzo (voice) | Rizzo (voice) |
 Byron MannJiahao (voice) | Jiahao (voice) |
 Osric ChauZhu (voice) | Zhu (voice) |
 Kiefer O'ReillyCharlie (voice) | Charlie (voice) |
 Zeus MendozaZuma (voice) | Zuma (voice) |
| SSean Patrick O'ReillyThurman (voice) | Thurman (voice) |
 Kingston ChanMei (voice) | Mei (voice) |
 Jack GillettBrian (voice) | Brian (voice) |
| AAlbert Steven TsaiZhang (voice) | Zhang (voice) |
 King LauKing Yufu (voice) | King Yufu (voice) |
 Rickie WangMin (voice) | Min (voice) |
| JJett WuMaly (voice) | Maly (voice) |
| MMichelle MyersOfficer Meyers (voice) | Officer Meyers (voice) |
 Jayne EastwoodHelen (voice) | Helen (voice) |