Henry Poole abandons his fiancée and family business to spend what he believes are his remaining days alone. The discovery of a 'miracle' by a nosy neighbor ruptures his solitude and restores his faith in life.
| Actor | Role |
|---|---|
 Luke WilsonHenry Poole | Henry Poole |
 George LópezFather Salizar | Father Salizar |
 Radha MitchellDawn Stupek | Dawn Stupek |
 Morgan LilyMillie Stupek | Millie Stupek |
 Adriana BarrazaEsperanza | Esperanza |
 Cheryl HinesMeg | Meg |
| EEarl CarrollMr. Lawrence | Mr. Lawrence |
| NNoah DahlYoung Henry Poole | Young Henry Poole |
 Rachel SeiferthPatience | Patience |
| NNick DashSecurity Guard | Security Guard |
 Andrew SantinoHospital Orderly | Hospital Orderly |
 Richard BenjaminDr. Fancher | Dr. Fancher |
 Beth GrantJosie | Josie |
 Sam JaegerLance | Lance |
 Molly HaganPediatrician | Pediatrician |
 Dan CallahanHospital Young Doctor | Hospital Young Doctor |
 Gloria GarayuaFemale Worshipper | Female Worshipper |
 Michelle KrusiecYoung Nurse | Young Nurse |