A guardian angel takes a gravely ill boy on a magical journey to meet legendary players from the New York Yankees, both past and present.
| Actor | Role |
|---|---|
 Richard GereHenry | Henry |
 Chazz PalminteriBabe Ruth | Babe Ruth |
 Cyndi LauperNurse Cyndi | Nurse Cyndi |
 Luis GuzmánLefty Gomez | Lefty Gomez |
 Danny AielloDr. Acosta | Dr. Acosta |
 Lucie ArnazJack's Mom | Jack's Mom |
 Nick SwisherSelf | Self |
 Paul SimonThurman Munson | Thurman Munson |
 Joseph GianJack's Dad | Jack's Dad |
 Reggie JacksonSelf | Self |
| AAustin WilliamsJack | Jack |
 Jason HarrisAdditional Voices | Additional Voices |
 Yogi BerraSelf | Self |
| MMichael KaySelf | Self |
| BBob SheppardStadium Announcer | Stadium Announcer |
 CC SabathiaSelf | Self |
 Bernie WilliamsSelf | Self |
| MMark TeixeiraSelf | Self |
| DDavid MantleMickey Mantle | Mickey Mantle |
| JJoe GirardiSelf | Self |
| NNancy NewmanNurse | Nurse |
| GGoose GossageSelf | Self |
| KKevin LongSelf | Self |
 Mariano RiveraSelf | Self |
| MMickey RiversSelf | Self |
| SScott ClarkBobby Murcer | Bobby Murcer |
| HHank SteinbrennerGeorge Steinbrenner | George Steinbrenner |
| JJohn SterlingSelf | Self |
| EEmily LashendockBaseball Fan | Baseball Fan |
| CCurtis GrandersonSelf | Self |