 Richard GereHenry (voice) | Henry (voice) |
 Chazz PalminteriBabe Ruth (voice) | Babe Ruth (voice) |
 Cyndi LauperNurse Cyndi (voice) | Nurse Cyndi (voice) |
 Luis GuzmánLefty Gomez (voice) | Lefty Gomez (voice) |
 Danny AielloDr. Acosta (voice) | Dr. Acosta (voice) |
 Lucie ArnazJack's Mom (voice) | Jack's Mom (voice) |
 Nick SwisherNick Swisher (voice) | Nick Swisher (voice) |
 Paul SimonThurman Munson (voice) | Thurman Munson (voice) |
 Joseph GianJack's Dad (voice) | Jack's Dad (voice) |
 Reggie JacksonReggie Jackson (voice) | Reggie Jackson (voice) |
| AAustin WilliamsJack (voice) | Jack (voice) |
 Jason HarrisAdditional Voices (voice) | Additional Voices (voice) |
 Yogi BerraYogi Berra (voice) | Yogi Berra (voice) |
| MMichael KayMichael Kay (voice) | Michael Kay (voice) |
| BBob SheppardStadium Announcer (voice) | Stadium Announcer (voice) |
 CC SabathiaCC Sabathia (voice) | CC Sabathia (voice) |
 Bernie WilliamsBernie Williams (voice) | Bernie Williams (voice) |
| MMark TeixeiraMark Teixeira (voice) | Mark Teixeira (voice) |
| DDavid MantleMickey Mantle (voice) | Mickey Mantle (voice) |
| JJoe GirardiJoe Girardi (voice) | Joe Girardi (voice) |
| NNancy NewmanNurse (voice) | Nurse (voice) |
| GGoose GossageGoose Gossage (voice) | Goose Gossage (voice) |
| KKevin LongKevin Long (voice) | Kevin Long (voice) |
 Mariano RiveraMariano Rivera (voice) | Mariano Rivera (voice) |
| MMickey RiversMickey Rivers (voice) | Mickey Rivers (voice) |
| SScott ClarkBobby Murcer (voice) | Bobby Murcer (voice) |
| HHank SteinbrennerGeorge Steinbrenner (voice) | George Steinbrenner (voice) |
| JJohn SterlingJohn Sterling (voice) | John Sterling (voice) |
| EEmily LashendockBaseball Fan (voice) | Baseball Fan (voice) |
| CCurtis GrandersonCurtis Granderson (voice) | Curtis Granderson (voice) |
