A folklore professor becomes unwittingly possessed by the ancient Japanese demons of Thunder and Lightning. But when The Bureau of Paranormal Research & Defense dispatches a team of agents to investigate, a cursed samurai sword sends Hellboy to a supernatural dimension of ghosts, monsters, and feudal mayhem. Now while pyrokinetic Liz Sherman and fishboy Abe Sapien battle one very pissed-off dragon, a lost and cranky Hellboy must find his way home.
| Actor | Role |
|---|---|
 Ron PerlmanHellboy (voice) | Hellboy (voice) |
 Selma BlairLiz Sherman (voice) | Liz Sherman (voice) |
 Doug JonesAbe Sapien (voice) | Abe Sapien (voice) |
 Peri GilpinProfessor Kate Corrigan (voice) | Professor Kate Corrigan (voice) |
 Gwendoline YeoKitsune (voice) | Kitsune (voice) |
 Dee Bradley BakerLightning / Kappa / Pilot (voice) | Lightning / Kappa / Pilot (voice) |
 Phil LaMarrBureau Member / Pilot / Additional Voices (voice) | Bureau Member / Pilot / Additional Voices (voice) |
 Mitchell WhitfieldRussell Thorne (voice) | Russell Thorne (voice) |
 Kim Mai GuestAdditional Voices (voice) | Additional Voices (voice) |
 Michael HagiwaraAdditional Voices (voice) | Additional Voices (voice) |
 Yuriana KimAdditional Voices (voice) | Additional Voices (voice) |
 Clyde KusatsuAdditional Voices (voice) | Additional Voices (voice) |
 Liza del MundoAdditional Voices (voice) | Additional Voices (voice) |
 Paul NakauchiAdditional Voices (voice) | Additional Voices (voice) |
 James SieAdditional Voices (voice) | Additional Voices (voice) |