When Hellboy, Liz Sherman, and Abe Sapien are assigned to investigate the ghost-infested mansion of a publicity-hound billionaire, they uncover a plot to resurrect a beautiful yet monstrous vampire from Professor Bruttenholm’s past. But before they can stop her bloodbath, Hellboy will have to battle harpies, hellhounds, a giant werewolf, and even the ferocious goddess Hecate herself.
| Actor | Role |
|---|---|
 Ron PerlmanHellboy (voice) | Hellboy (voice) |
 Selma BlairLiz Sherman (voice) | Liz Sherman (voice) |
 Doug JonesAbe Sapien (voice) | Abe Sapien (voice) |
 John HurtProfessor Trevor 'Broom' Bruttenholm (voice) | Professor Trevor 'Broom' Bruttenholm (voice) |
 Peri GilpinProfessor Kate Corrigan (voice) | Professor Kate Corrigan (voice) |
 J. Grant AlbrechtOliver Trombolt (voice) | Oliver Trombolt (voice) |
 Jim CummingsTom Manning (voice) | Tom Manning (voice) |
 Grey DeLisleAnna / Harpy-Hag #2 (voice) | Anna / Harpy-Hag #2 (voice) |
 Rob PaulsenSydney Leach / Anna's Fiance (voice) | Sydney Leach / Anna's Fiance (voice) |
 Kath SoucieErzsebet Ondrushko (voice) | Erzsebet Ondrushko (voice) |
 DeeDee RescherHarpy-Hag #1 (voice) | Harpy-Hag #1 (voice) |
 Cree SummerHecate (voice) | Hecate (voice) |
 James Arnold TaylorYoung Broom / Father Lupescu (voice) | Young Broom / Father Lupescu (voice) |