Helene is based on Helene Wilfur, a novel by Vicki (Grand Hotel) Baum. Madeleine Renaud essays the title role, a young medical student in love with aspiring musician Pierre Regnier (Jean-Lous Barrault). Pierre's father, a noted surgeon, puts pressure on his son to give up music in favor of medicine. Unable to withstand his father's remonstrations, Pierre kills himself, prompting the grieving Madeleine to forget all about romance and dedicate her life to the cause of healing others. Wilfur avoids the usual soap-opera goo by offering realistic performances and credible dialogue (the English-language subtitles were composed by erudite film critic Herman G. Weinberg).
| Actor | Role |
|---|---|
 Madeleine RenaudHélène Wilfur | Hélène Wilfur |
 Jean-Louis BarraultPierre Régnier | Pierre Régnier |
 Constant RémyProfessor Amboise | Professor Amboise |
 Héléna MansonValérie | Valérie |
 Odette JoyeuxFrançoise | Françoise |
 Robert Le ViganDoctor Regnier | Doctor Regnier |
 Georges BeverThe lab boy | The lab boy |
| JJeanne HelblingYvonne Amboise | Yvonne Amboise |
| BBlanche PeyrensThe doctor | The doctor |
| GGreta BuelensTotoche | Totoche |
| MMarguerite DaulboysThe widow | The widow |
 René DaryMarcel | Marcel |
 Maurice BaquetDurant Tout Court | Durant Tout Court |
 Paul EscoffierThe judge | The judge |
 Armand LurvilleThe dean | The dean |
| TTsugundo MakiThe Japanese student | The Japanese student |
 Roger TozinyThe bookstore | The bookstore |
 Juozas MiltinisThe Russian | The Russian |
 Gaby AndréNot listed | Not listed |
 Gilberte GéniatNot listed | Not listed |
 Pierre-LouisNot listed | Not listed |
| PPierre SardaNot listed | Not listed |