The "true story" of baseball great Babe Ruth; Ruth plays himself.
| Actor | Role |
|---|---|
 Babe RuthBabe (as George Herman 'Babe' Ruth) | Babe (as George Herman 'Babe' Ruth) |
 Ruth TaylorMildred Tobin | Mildred Tobin |
| WWilliam SheerHarry Knight | Harry Knight |
 Margaret SeddonBabe's Mother | Babe's Mother |
| FFrances VictoryPigtails | Pigtails |
 James A. MarcusSimon Tobin | Simon Tobin |
 Ralf HaroldeJohn Tobin (as Ralph Harolds) | John Tobin (as Ralph Harolds) |
| CCharles ByerDavid Talmadge (as Charles Burt) | David Talmadge (as Charles Burt) |
| GGeorge HalpinDoc Hedges / The Constable / Dog Catcher | Doc Hedges / The Constable / Dog Catcher |
| WWilliam J. GrossEliar Lott | Eliar Lott |
| WWalter LawrenceTony Marino | Tony Marino |
 Ann BrodyMrs. Tony Marino (as Anne Brodie) | Mrs. Tony Marino (as Anne Brodie) |
 Ricca AllenAlmira Worters | Almira Worters |
 Sammy BlumJimbo Jones (as Sam Blum) | Jimbo Jones (as Sam Blum) |
| EEthel KerwinKitty Wilson | Kitty Wilson |
| TTom CameronDeacon Flack (as Thomas Cameron) | Deacon Flack (as Thomas Cameron) |
| CCharles J. HuntReverend David Talmadge | Reverend David Talmadge |